Manchester United manager Jose Mourinho and his Manchester City adversary Guardiola rekindle a rivalry 20 years in the making in this weekend's hotly anticipated Manchester derby.
Friends who became foes, Mourinho and Guardiola represent opposite ends of football's ideological spectrum and their ongoing grudge match has shaped the game's recent history.
It is three years since they last shared a touchline and Saturday's clash at Old Trafford marks the resumption of a duel that could determine the outcome of the Premier League title race.
"He (Guardiola) left Barcelona for a number of reasons," former Liverpool defender Jamie Carragher wrote in the Daily Mail when Mourinho was appointed by United in May.
"But one of them, I'm sure, is the continual baiting to which he was subjected by Mourinho in the media.
"It is inevitable, at some point, that theme will return. Guardiola must be thinking: 'Oh no, not him again.'"
Though renowned for their different demeanours, the pragmatic Mourinho, 53, and the idealistic Guardiola, 45, have both shown a capacity for ruthlessness in their early days in Manchester.
Mourinho has sidelined experienced German midfielder Bastian Schweinsteiger, while Guardiola's benching of Joe Hart forced the popular goalkeeper to leave City for Torino.
Both men have also delivered impressive initial results, leaving their clubs neck-and-neck on nine points – along with Chelsea – after the first three games of the season.
It is two decades since their paths first crossed at Barcelona in the mid-1990s, when Guardiola was captain and Mourinho worked as an assistant to Bobby Robson and Louis van Gaal.
The pair became close, but they found themselves in opposition at Camp Nou in 2008 when Barcelona went in search of a successor to Frank Rijkaard as manager.
Despite Mourinho's stellar achievements with Porto and Chelsea, he was overlooked in favour of the inexperienced Guardiola.
The Portuguese exacted sweet revenge two years later when Inter Milan knocked defending champions Barca out of the Champions League.
In an iconic image, Mourinho raced across the Camp Nou pitch in celebration, his right hand provocatively raised in the air.